American Institutes for Research is conducting a synthesis of two largely separate bodies of literature on undergraduate STEM classroom interventions: (a) motivational interventions (e.g., values affirmation) and (b) instructional interventions (e.g., active learning). The synthesis will include both experimental and quasi-experimental evaluations of these interventions, focusing on effects for retention (e.g., taking the next STEM course, graduating with a STEM degree) and motivational factors related to retention (e.g., interests, self-efficacy, sense of belonging). Additional moderation analyses will investigate how intervention design features, student demographics, and the implementation context may help explain why some studies show stronger effects than others.